β-1,4-Galactosyltransferase III suppresses β1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer Chia-Hua Chen1, Shui-Hua Wang2, Chiung-Hui Liu1, Yi-Ling Wu1, Wei-Jen Wang1, John Huang3, Ji-Shiang Hung3,4, I-Rue Lai1,3, Jin-Tung Liang3 and Min-Chuan Huang1,5,*
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چکیده
1Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 10051, Taiwan, 2Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan, 3Department of Surgery and 4Department of Medical Research, National Taiwan University Hospital, Taipei 10048, Taiwan and 5Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 10041, Taiwan
منابع مشابه
β-1,4-Galactosyltransferase III enhances invasive phenotypes via β1-integrin and predicts poor prognosis in neuroblastoma.
PURPOSE Neuroblastoma (NB) is a neural crest-derived tumor that commonly occurs in childhood. β-1,4-Galactosyltransferase III (B4GALT3) is highly expressed in human fetal brain and is responsible for the generation of poly-N-acetyllactosamine, which plays a critical role in tumor progression. We therefore investigated the expression and role of B4GALT3 in NB. EXPERIMENTAL DESIGN We examined B...
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Cancer cell invasion and metastasis are the primary causes of treatment failure and death in hepatocellular carcinoma (HCC). We previously reported that core 1 β1,3-galactosyltransferase (C1GALT1) is frequently overexpressed in HCC tumors and its expression is associated with advanced tumor stage, metastasis, and poor survival. However, the underlying mechanisms of C1GALT1 in HCC malignancy rem...
متن کاملHuman Cancer Biology b-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via b1-Integrin and Predicts Poor Prognosis in Neuroblastoma
Purpose: Neuroblastoma (NB) is a neural crest-derived tumor that commonly occurs in childhood. b-1,4-Galactosyltransferase III (B4GALT3) is highly expressed inhuman fetal brain and is responsible for the generation of poly-N-acetyllactosamine, which plays a critical role in tumor progression. We therefore investigated the expression and role of B4GALT3 in NB. Experimental Design:We examined B4G...
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Core 1 β1,3-galactosyltransferase (C1GALT1) transfers galactose (Gal) to N-acetylgalactosamine (GalNAc) to form Galβ1,3GalNAc (T antigen). Aberrant O-glycans, such as T antigen, are commonly found in colorectal cancer. However, the role of C1GALT1 in colorectal cancer remains unclear. Here we showed that C1GALT1 was frequently overexpressed in colorectal tumors and is associated with poor survi...
متن کاملβ1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells
Cancer stem cells are cancer cells characterized with tumor initiating capacity. β1,4-N-acetylgalactosaminyltransferase III (B4GALNT3) synthesizes GalNAcβ1-4GlcNAc (LacdiNAc) which contributes to self-renewal of mouse embryonic stem cells. We previously showed that B4GALNT3 overexpression enhances colon cancer cell malignant phenotypes in vitro and in vivo. However, the role of B4GALNT3 in canc...
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تاریخ انتشار 2014